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Article

Copper differentially regulates the activity and degradation of yeast Mac1 transcription factor.

The Journal of biological chemistry - 16 Jan 1998

Zhu Z, Labbé S, Peña M M, Thiele D J

Abstract excerpt

Copper is an essential metal ion that is toxic when accumulated to high intracellular concentrations. The yeast Mac1 protein is a copper-sensing transcription factor that is essential for both the activation and inactivation of genes required for high affinity copper ion transport. Here we demonstrate that in response to low copper ion concentrations Mac1 protein is rendered inactive for copper transporter gene...

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PMID: 9430656
DOI: 10.1074/jbc.273.3.1277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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