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Article

Copper sensing function of Drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear Cu(I) cluster.

Nucleic acids research - 1 May 2008

Chen Xiaohua, Hua Haiqing, Balamurugan Kuppusamy, Kong Xiangming, Zhang Limei, George Graham N, Georgiev Oleg, Schaffner Walter, Giedroc David P

Abstract excerpt

Drosophila melanogaster MTF-1 (dMTF-1) is a copper-responsive transcriptional activator that mediates resistance to Cu, as well as Zn and Cd. Here, we characterize a novel cysteine-rich domain which is crucial for sensing excess intracellular copper by dMTF-1. Transgenic flies expressing mutant dMTF-1 containing alanine substitutions of two, four or six cysteine residues within the sequence...

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PMID: 18411209
DOI: 10.1093/nar/gkn103
PMCID: PMC2396432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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