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Article

Analysis of mutations in oral poliovirus vaccine by hybridization with generic oligonucleotide microchips.

Biologicals : journal of the International Association of Biological Standardization - 1 Jun 2000

Proudnikov D, Kirillov E, Chumakov K, Donlon J, Rezapkin G, Mirzabekov A

Abstract excerpt

This paper describes use of a new technology of hybridization with a micro-array of immobilized oligonucleotides for detection and quantification of neurovirulent mutants in Oral Poliovirus Vaccine (OPV). We used a micro-array consisting of three-dimensional gel-elements containing all possible hexamers (total of 4096 probes). Hybridization of fluorescently labelled viral cDNA samples with such microchips...

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Identifiers

PMID: 10885613
DOI: 10.1006/biol.1999.0241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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