Article
Microarray assay for evaluation of the genetic stability of modified vaccinia virus Ankara B5R gene.
Journal of medical virology - 1 Jun 2007
Laassri Majid, Meseda Clement A, Williams Ollie, Merchlinsky Michael, Weir Jerry P, Chumakov Konstantin
Abstract excerpt
Adverse events associated with the use of live smallpox vaccines have led to the development of a new generation of attenuated smallpox vaccines that are prepared in cultured cells as alternatives. The inability to conduct direct clinical evaluation of their efficacy in humans demands that licensure be based on animal studies and exhaustive evaluation of their in vitro properties. One of the most important...
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