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Article

Multiple mechanisms underlie HLA dysregulation in cervical cancer.

Tissue antigens - 1 May 2000

Brady C S, Bartholomew J S, Burt D J, Duggan-Keen M F, Glenville S, Telford N, Little A M, Davidson J A, Jimenez P, Ruiz-Cabello F, Garrido F, Stern P L

Abstract excerpt

The consistent dysregulation of HLA expression in cervical neoplasia is likely to influence the natural history of the disease and prospects for cell-mediated vaccine therapies. We have studied the underlying mechanisms in eight new cervical cancer cell lines derived from primary tumour biopsies. At least five independent mechanisms leading to changes in HLA expression were seen: HLA class I allelic transcription...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10885560
DOI: 10.1034/j.1399-0039.2000.550502.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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