Article
HLA class I phenotype and genotype alterations in cervical carcinomas and derivative cell lines.
Tissue antigens - 1 Jun 1998
Koopman L A, Mulder A, Corver W E, Anholts J D, Giphart M J, Claas F H, Fleuren G J
Abstract excerpt
Downregulation of HLA class I expression is a common event in tumor biology. Various underlying mechanisms have been defined in different tumors, but the knowledge of HLA loss mechanisms in cervical carcinoma is limited. To identify causalities for loss of surface expression, we performed a detai...
Topics
- Alleles
- Animals
- DNA Primers
- Female
- Genotype
- Histocompatibility Antigens Class I
- Humans
- Interferon-gamma
- Mice
- Microsatellite Repeats
- Phenotype
- Polymerase Chain Reaction
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha
- Uterine Cervical Neoplasms