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Article

Frequency of down-regulation of individual HLA-A and -B alleles in cervical carcinomas in relation to TAP-1 expression.

British journal of cancer - 1 Aug 1995

Keating P J, Cromme F V, Duggan-Keen M, Snijders P J, Walboomers J M, Hunter R D, Dyer P A, Stern P L

Abstract excerpt

The development of cervical carcinoma is strongly associated with specific types of human papillomaviruses (HPVs). A role for cellular immunity in cervical disease is supported by the increased occurrence of HPV-associated lesions in immunosuppressed individuals. Upon viral infection or malignant transformation, ensuing alterations in gene expression result in the generation of novel sets of peptides which can...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP-Binding Cassette Transporters
Adenocarcinoma
Adult
Aged
Aged, 80 and over
Alleles
Biopsy
Carcinoma, Squamous Cell
Cervix Uteri

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Down-Regulation

Female

Gene Deletion

Gene Expression Regulation, Neoplastic

HLA-A Antigens

HLA-B Antigens

Heterozygote

Humans

Source

Open in PubMed Open full text

Identifiers

PMID: 7640226
DOI: 10.1038/bjc.1995.346
PMCID: PMC2033975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7640226-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Frequency of down-regulation of individual HLA-A and -B alleles in cervical carcinomas in relation to TAP-1 expression.PMID 7640226Read ↗

Deficient expression of components of the MHC class I antigen processing machinery in human cervical carcinoma.Semantic proximity Read ↗

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Multiple mechanisms underlie HLA dysregulation in cervical cancer.Semantic proximity Read ↗

The Role of HLA Class I Genes in Genital HPV Pathogenesis in African Women: A ReviewSemantic proximity Read ↗

The expression of histocompatibility-related leukocyte antigens in the pathway to cervical carcinoma.Semantic proximity Read ↗

The antigen processing-associated transporter gene polymorphism: Role on gene and protein expression in HPV-infected pre-cancerous cervical lesion.Semantic proximity Read ↗

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