Article
Selection of drug-resistant variants in the female genital tract of human immunodeficiency virus type 1-infected women receiving antiretroviral therapy.
The Journal of infectious diseases - 1 Jul 2000
Si-Mohamed A, Kazatchkine M D, Heard I, Goujon C, Prazuck T, Aymard G, Cessot G, Kuo Y H, Bernard M C, Diquet B, Malkin J E, Gutmann L, Bélec L
Abstract excerpt
We investigated human immunodeficiency virus (HIV) type 1 RNA, proviral DNA, and antiretroviral drug-resistant variants in cervicovaginal secretions of HIV-1-infected women receiving antiretroviral therapy. The prevalence of detectable HIV-1 RNA in genital secretions was inversely related to the number of antiretroviral drugs taken by the patients. Proviral DNA was detected in approximately half of all samples of...
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