Article
HIV-1 drug resistance in variants from the female genital tract and plasma.
The Journal of infectious diseases - 15 Feb 2007
Kemal Kimdar Sherefa, Burger Harold, Mayers Douglas, Anastos Kathryn, Foley Brian, Kitchen Christina, Huggins Penelope, Schroeder Tamara, Picchio Gaston, Back Sara, Gao Wei, Meyer William A, Weiser Barbara
Abstract excerpt
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) drug-resistance mutations may arise in a fraction of viral variants, and these variants may differ between compartments, including the genital tract and blood. METHODS: We studied 14 women with detectable HIV-1 in both the genital tract and plasma despite antiretroviral treatment. We obtained HIV-1 RNA sequences from 280 unique viral variants and then...
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