Article
Cellular replication of human immunodeficiency virus type 1 occurs in vaginal secretions.
The Journal of infectious diseases - 1 Jul 2001
Ellerbrock T V, Lennox J L, Clancy K A, Schinazi R F, Wright T C, Pratt-Palmore M, Evans-Strickfaden T, Schnell C, Pai R, Conley L J, Parrish-Kohler E E, Bush T J, Tatti K, Hart C E
Abstract excerpt
Most human immunodeficiency virus type 1 (HIV-1) transmission worldwide is the result of exposure to infectious virus in genital secretions. However, current vaccine candidates are based on virus isolates from blood. In this study, vaginal secretions from HIV-1-infected women were examined for evidence of cellular viral replication that produced virus with properties different from that in blood. Multiply spliced...
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