Article
Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus.
The Journal of infectious diseases - 1 Jul 2000
Neumann A U, Lam N P, Dahari H, Davidian M, Wiley T E, Mika B P, Perelson A S, Layden T J
Abstract excerpt
Many studies have shown that patients infected with hepatitis C virus (HCV) of genotype 2 have better response to interferon (IFN)-alpha treatment than genotype 1 patients; however, the mechanisms responsible for this difference are not understood. In this study, viral dynamics during high-dose IFN induction treatment were compared between the genotypes. Patients in each group received 10 MU of IFN-alpha2b for 14...
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