Article
Viral dynamics and pharmacokinetics in combined interferon alfa-2b and ribavirin therapy for patients infected with hepatitis C virus of genotype 1b and high pretreatment viral load.
Intervirology - 1 Jan 2002
Tsubota Akihito, Akuta Norio, Suzuki Fumitaka, Suzuki Yoshiyuki, Someya Takahi, Kobayashi Masahiro, Arase Yasuji, Saitoh Satoshi, Ikeda Kenji, Kumada Hiromitsu
Abstract excerpt
OBJECTIVE: The aim of this study was to clarify the viral dynamics and single- and multiple-dose pharmacokinetics of ribavirin and interferon (IFN) alfa-2b in the virologic response to combination therapy with both compounds in patients infected with hepatitis C virus (HCV) genotype 1b and high viral load. METHODS: Fourteen patients received high-dose daily induction therapy followed by intermittent maintenance...
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