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Article

A perspective on modelling hepatitis C virus infection

15 Aug 2010

Abstract excerpt

By mathematically describing early hepatitis C virus (HCV) RNA decay after initiation of interferon (IFN)-based antiviral therapy, crucial parameters of the in vivo viral kinetics have been estimated, such as the rate of production and clearance of free virus, and the rate of loss of infected cells. Furthermore, by suggesting mechanisms of action for IFN and ribavirin mathematical modelling has provided a means...

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PMID: 20723038
DOI: 10.1111/j.1365-2893.2010.01348.x

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