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Article

Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases.

Molecular cell - 23 May 2013

Bagola Katrin, von Delbrück Maximilian, Dittmar Gunnar, Scheffner Martin, Ziv Inbal, Glickman Michael H, Ciechanover Aaron, Sommer Thomas

Abstract excerpt

Ubiquitin-binding domains (UBDs) differentially recognize ubiquitin (ub) modifications. Some of them specifically bind mono-ub, as has been shown for the CUE domain. Interestingly, so far no significant ubiquitin binding has been observed for the CUE domain of yeast Cue1p. Cue1p is receptor and activator of the ubiquitin-conjugating enzyme Ubc7p. It integrates Ubc7p into endoplasmic reticulum (ER) membrane-bound...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23665229
DOI: 10.1016/j.molcel.2013.04.005

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UBD

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