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Article

Expression of guanylin is downregulated in mouse and human intestinal adenomas.

Biochemical and biophysical research communications - 24 Jun 2000

Steinbrecher K A, Tuohy T M, Heppner Goss K, Scott M C, Witte D P, Groden J, Cohen M B

Abstract excerpt

Guanylin is a pro-secretory hormone that is expressed in intestinal epithelia. Previously, we mapped the guanylin gene to mouse and human chromosomal regions containing multiple intestinal tumor-modifying loci. Here, we investigate whether guanylin expression is downregulated in precancerous human and mouse intestinal adenomas and whether diminished guanylin expression increases adenoma susceptibility in an...

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Identifiers

PMID: 10873591
DOI: 10.1006/bbrc.2000.2917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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