The genetics of common diseases: the implications of population variability.

Abstract excerpt

The results of recent work on the inheritance of susceptibility to malaria suggest that, over what may have been a relatively short evolutionary period, a remarkably diverse series of gene families have been modified in response to the selective drive of this infectious disease. The phenotypic consequences are not confined to the erythrocyte, they also involve the immune system, cytokines and many other systems....

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