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Article

A novel functional genomics approach identifies mTERT as a suppressor of fibroblast transformation.

Nucleic acids research - 1 Jul 2000

Li Q X, Robbins J M, Welch P J, Wong-Staal F, Barber J R

Abstract excerpt

As a tool for functional genomics, a hairpin ribozyme gene library with randomized target recognition sequences was constructed in a retroviral vector. This library has the potential to target and cleave any possible RNA substrate. Mouse fibroblasts transduced with this ribozyme gene vector library were selected in a focus formation assay to isolate in vivo functional ribozymes that promote cell transformation in...

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Identifiers

PMID: 10871412
DOI: 10.1093/nar/28.13.2605
PMCID: PMC102704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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