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Article

Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases.

Scientific reports - 18 Sept 2014

Mock Ulrike, Riecken Kristoffer, Berdien Belinda, Qasim Waseem, Chan Emma, Cathomen Toni, Fehse Boris

Abstract excerpt

TAL-effector nucleases (TALENs) are attractive tools for sequence-specific genome modifications, but their delivery still remains problematic. It is well known that the presence of multiple sequence repeats in TALEN genes hampers the use of lentiviral vectors. We report that lentiviral vectors readily package full-length vector mRNAs encoding TALENs, but recombination during reverse transcription prevents...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25230987
DOI: 10.1038/srep06409
PMCID: PMC4166709

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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