Article
Diverse genetic mechanisms operate to generate atypical betaS haplotypes in the population of Guadeloupe.
Hemoglobin - 1 May 2000
Romana M, Kéclard L, Froger A, Lavocat E, Saint-Martin C, Berchel C, Mérault G
Abstract excerpt
In a survey of the chromosomal background associated with the sickle cell gene in Guadeloupe, a French Caribbean island, we identified 37 unrelated patients with sickle cell disease (27 SS, nine SC, and one S-beta-thalassemia) of 477 unrelated sickle cell patients where the beta3 gene was linked to 20 different atypical haplotypes. These atypical chromosomes account for about 5% of the overall betaS chromosomes...
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