Article
Beta-globin gene cluster haplotypes and alpha-thalassemia in sickle cell disease patients from Trinidad.
American journal of human biology : the official journal of the Human Biology Council - 1 Jan 2000
Jones-Lecointe Altheia, Smith Erskine, Romana Marc, Gilbert Marie-Georges, Charles Waveney P, Saint-Martin Christian, Kéclard Lisiane
Abstract excerpt
In this study, we have determined the frequency of beta(S) haplotypes in 163 sickle cell disease patients from Trinidad. The alpha(3.7) globin gene deletion status was also studied with an observed gene frequency of 0.17. Among the 283 beta(S) chromosomes analyzed, the Benin haplotype was the most prevalent (61.8%) followed by Bantu (17.3%), Senegal (8.5%), Cameroon (3.5%), and Arab-Indian (3.2%), while 5.7% of...
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