Article

Resolution of the circulating pathogenic phenotype of alpha-1 antitrypsin deficiency following liver transplantation

2025-12-02

Abstract excerpt

Alpha-1 antitrypsin is a member of the serpin family of protease inhibitors and normally found in monomeric form at high concentration in the circulation. Certain pathogenic variants of this protein self-assemble into flexible chains (polymers) that undergo toxic accumulation in the liver, underlying the development of liver disease, and a corresponding functional deficiency in circulation results in a susceptibil...

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Literature Corpus work: 3ca3cc74-f697-56ab-adac-c395d2a63013
DOI: 10.64898/2025.11.29.691315

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