Article
Early development of mouse embryos null mutant for the cyclin A2 gene occurs in the absence of maternally derived cyclin A2 gene products.
Developmental biology - 1 Jul 2000
Winston N, Bourgain-Guglielmetti F, Ciemerych M A, Kubiak J Z, Senamaud-Beaufort C, Carrington M, Bréchot C, Sobczak-Thépot J
Abstract excerpt
Progression through the mammalian cell cycle is regulated by the sequential activation and inactivation of the cyclin-dependent kinases. In adult cells, cyclin A2-dependent kinases are required for entry into S and M phases, completion of S phase, and centrosome duplication. However, mouse embryos lacking the cyclin A2 gene nonetheless complete preimplantation development, but die soon after implantation. In this...
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