Article
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 1998
Brandeis M, Rosewell I, Carrington M, Crompton T, Jacobs M A, Kirk J, Gannon J, Hunt T
Abstract excerpt
Two B-type cyclins, B1 and B2, have been identified in mammals. Proliferating cells express both cyclins, which bind to and activate p34(cdc2). To test whether the two B-type cyclins have distinct roles, we generated lines of transgenic mice, one lacking cyclin B1 and the other lacking cyclin B2. Cyclin B1 proved to be an essential gene; no homozygous B1-null pups were born. In contrast, nullizygous B2 mice...
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