Article
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 1998
Brandeis M, Rosewell I, Carrington M, Crompton T, Jacobs M A, Kirk J, Gannon J, Hunt T
Abstract excerpt
Two B-type cyclins, B1 and B2, have been identified in mammals. Proliferating cells express both cyclins, which bind to and activate p34(cdc2). To test whether the two B-type cyclins have distinct roles, we generated lines of transgenic mice, one lacking cyclin B1 and the other lacking cyclin B2....
Topics
- 3T3 Cells
- Animals
- Cell Membrane
- Cloning, Organism
- Cyclin B
- Cyclin B1
- Evolution, Molecular
- Female
- Fertility
- Fetal Death
- Gene Expression Regulation, Developmental
- Genetic Variation
- Humans
- Male
- Mice
- Mice, Knockout
- Phylogeny
- Pregnancy