Article
A deletion encompassing Zic3 in bent tail, a mouse model for X-linked neural tube defects.
Human molecular genetics - 1 Jul 2000
Klootwijk R, Franke B, van der Zee C E, de Boer R T, Wilms W, Hol F A, Mariman E C
Abstract excerpt
Bent tail is a mouse model for human neural tube defects. Bent tail mice are characterized by a shortened, kinked tail. We have observed numerous aberrations in Bent tail embryos including exencephaly, rotation defects and occasionally omphalocele, orofacial schisis and situs abnormalities. Exencephaly was seen in >10% of all embryos and resulted from a closure defect of the hindbrain. Bent tail maps to the...
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