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Article

Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark

16 Apr 2003

Abstract excerpt

Grb10/GRB10 encodes a cytoplasmic adapter protein which modulates coupling of a number of cell surface receptor tyrosine kinases with specific signalling pathways. Mouse Grb10 is an imprinted gene with maternal-specific expression. In contrast, human GRB10 is expressed biallelically in most tissues, except for maternal-specific expression of one isoform in muscle and paternal expression in fetal brain. Owing to...

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PMID: 12700169
DOI: 10.1093/hmg/ddg110

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Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same markPMID 12700169Read ↗

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