Article
Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH.
Gastroenterology - 1 Jul 2006
Chow Elizabeth, Lipton Lara, Lynch Elly, D'Souza Rebecca, Aragona Clelia, Hodgkin Lindy, Brown Gregor, Winship Ingrid, Barker Melissa, Buchanan Daniel, Cowie Shannon, Nasioulas Steve, du Sart Desiree, Young Joanne, Leggett Barbara, Jass Jeremy, Macrae Finlay
Abstract excerpt
BACKGROUND & AIMS: Hyperplastic polyposis syndrome (HPS) is defined phenotypically with multiple, large and/or proximal hyperplastic polyps. There is no known germ-line predisposition. We aimed to characterize the clinicopathologic features of 38 patients with HPS and explore the role of germ-line mutations in the base excision repair genes MBD4 and MYH. METHODS: Utilizing clinical databases of The Royal...
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