Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.

doi:10.1016/j.neuron.2013.07.037

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Article

Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.

Neuron - 18 Sept 2013

Maruyama Masahiro, Shimada Hitoshi, Suhara Tetsuya, Shinotoh Hitoshi, Ji Bin, Maeda Jun, Zhang Ming-Rong, Trojanowski John Q, Lee Virginia M-Y, Ono Maiko, Masamoto Kazuto, Takano Harumasa, Sahara Naruhiko, Iwata Nobuhisa, Okamura Nobuyuki, Furumoto Shozo, Kudo Yukitsuka, Chang Qing, Saido Takaomi C, Takashima Akihiko, Lewis Jada, Jang Ming-Kuei, Aoki Ichio, Ito Hiroshi, Higuchi Makoto

Abstract excerpt

Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models of these disorders....

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Identifiers

PMID: 24050400
DOI: 10.1016/j.neuron.2013.07.037
PMCID: PMC3809845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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