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Article

Evaluating Drosophila p53 as a model system for studying cancer mutations.

The Journal of biological chemistry - 28 Dec 2012

Herzog Gal, Joerger Andreas C, Shmueli Merav D, Fersht Alan R, Gazit Ehud, Segal Daniel

Abstract excerpt

The transcription factor p53 is a key tumor suppressor protein. In about half of human cancers, p53 is inactivated directly through mutation in its sequence-specific DNA-binding domain. Drosophila p53 (Dmp53) has similar apoptotic functions as its human homolog and is therefore an attractive model system for studying cancer pathways. To probe the structure and function of Dmp53, we studied the effect of point...

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Identifiers

PMID: 23135266
DOI: 10.1074/jbc.M112.417980
PMCID: PMC3531747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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