Article
Effects of passage history and sampling bias on phylogenetic reconstruction of human influenza A evolution.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 2000
Bush R M, Smith C B, Cox N J, Fitch W M
Abstract excerpt
In this paper we determine the extent to which host-mediated mutations and a known sampling bias affect evolutionary studies of human influenza A. Previous phylogenetic reconstruction of influenza A (H3N2) evolution using the hemagglutinin gene revealed an excess of nonsilent substitutions assigned to the terminal branches of the tree. We investigate two hypotheses to explain this observation. The first...
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