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Article

Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification.

Journal of virology - 15 Dec 2016

Sobel Leonard Ashley, McClain Micah T, Smith Gavin J D, Wentworth David E, Halpin Rebecca A, Lin Xudong, Ransier Amy, Stockwell Timothy B, Das Suman R, Gilbert Anthony S, Lambkin-Williams Robert, Ginsburg Geoffrey S, Woods Christopher W, Koelle Katia

Abstract excerpt

Knowledge of influenza virus evolution at the point of transmission and at the intrahost level remains limited, particularly for human hosts. Here, we analyze a unique viral data set of next-generation sequencing (NGS) samples generated from a human influenza challenge study wherein 17 healthy subjects were inoculated with cell- and egg-passaged virus. Nasal wash samples collected from 7 of these subjects were...

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Identifiers

PMID: 27707932
DOI: 10.1128/JVI.01657-16
PMCID: PMC5126380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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