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Article

Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor.

Antimicrobial agents and chemotherapy - 1 Feb 2001

Clements J M, Beckett R P, Brown A, Catlin G, Lobell M, Palan S, Thomas W, Whittaker M, Wood S, Salama S, Baker P J, Rodgers H F, Barynin V, Rice D W, Hunter M G

Abstract excerpt

Peptide deformylase (PDF) is an essential bacterial metalloenzyme which deformylates the N-formylmethionine of newly synthesized polypeptides and as such represents a novel target for antibacterial chemotherapy. To identify novel PDF inhibitors, we screened a metalloenzyme inhibitor library and identified an N-formyl-hydroxylamine derivative, BB-3497, and a related natural hydroxamic acid antibiotic, actinonin,...

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Identifiers

PMID: 11158755
DOI: 10.1128/AAC.45.2.563-570.2001
PMCID: PMC90327

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PDF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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