Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.

doi:10.1128/AAC.01103-06

Article

Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.

Antimicrobial agents and chemotherapy - 1 Mar 2007

Dean Charles R, Narayan Shubha, Richards Joel, Daigle Denis M, Esterow Stacy, Leeds Jennifer A, Kamp Heather, Puyang Xiaoling, Wiedmann Brigitte, Mueller Dieter, Voshol Hans, van Oostrum Jan, Wall Daniel, Koehn James, Dzink-Fox Joann, Ryder Neil S

Abstract excerpt

Previous genetic analysis of Haemophilus influenzae revealed two mechanisms associated with decreased susceptibility to the novel peptide deformylase inhibitor LBM415: AcrAB-TolC-mediated efflux and Fmt bypass, resulting from mutations in the pump repressor gene acrR and in the fmt gene, respectively. We have isolated an additional mutant, CDS23 (LBM415 MIC, 64 microg/ml versus 4 microg/ml against the parent...

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Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.

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