Article
Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins.
International journal of molecular sciences - 31 Dec 2021
Yesmin Farhana, Bhuiyan Robiul H, Ohmi Yuhsuke, Yamamoto Satoko, Kaneko Kei, Ohkawa Yuki, Zhang Pu, Hamamura Kazunori, Cheung Nai-Kong V, Kotani Norihiro, Honke Koichi, Okajima Tetsuya, Kambe Mariko, Tajima Orie, Furukawa Keiko, Furukawa Koichi
Abstract excerpt
Gangliosides have been considered to modulate cell signals in the microdomain of the cell membrane, lipid/rafts, or glycolipid-enriched microdomain/rafts (GEM/rafts). In particular, cancer-associated gangliosides were reported to enhance the malignant properties of cancer cells. In fact, GD2-positive (GD2+) cells showed increased proliferation, invasion, and adhesion, compared with GD2-negative (GD2-) cells....
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