Article
Common phenotypic expression of gangliosides GM3 and GD3 in normal human tissues and neoplastic skin lesions.
Japanese journal of clinical oncology - 1 Oct 1992
Nakakuma H, Horikawa K, Kawaguchi T, Hidaka M, Nagakura S, Hirai S, Kageshita T, Ono T, Kagimoto T, Iwamori M
Abstract excerpt
The expression of gangliosides in non-malignant tissues (epidermis and pigmented nevus) and neoplastic lesions (melanoma, squamous cell carcinoma [SCC] and basal cell carcinoma [BCS]) of the human skin was analyzed immunohistochemically and biochemically to characterize the features associated with malignancy. Immunohistochemical staining with an anti-II3NeuAc-LacCer (GM3) monoclonal antibody (M2590 mAb) and an...
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