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Article

Identification of amino acid residues in the Caenorhabditis elegans POU protein UNC-86 that mediate UNC-86-MEC-3-DNA ternary complex formation.

Molecular and cellular biology - 1 Jul 2000

Röckelein I, Röhrig S, Donhauser R, Eimer S, Baumeister R

Abstract excerpt

The POU homeodomain protein UNC-86 and the LIM homeodomain protein MEC-3 are essential for the differentiation of the six mechanoreceptor neurons in the nematode Caenorhabditis elegans. Previous studies have indicated that UNC-86 and MEC-3 bind cooperatively to at least three sites in the mec-3 promoter and synergistically activate transcription. However, the molecular details of the interactions of UNC-86 with...

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Identifiers

PMID: 10848606
DOI: 10.1128/MCB.20.13.4806-4813.2000
PMCID: PMC85923

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