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Malassezia responds to environmental pH signals through the conserved Rim/Pal pathway

27 Aug 2024

Abstract excerpt

ABSTRACT During mammalian colonization and infection, microorganisms must be able to rapidly sense and adapt to changing environmental conditions including alterations in extracellular pH. The fungus-specific Rim/Pal signaling pathway is one process that supports microbial adaptation to alkaline pH. This cascading series of interacting proteins terminates in the proteolytic activation of the highly conserved...

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PMID: 39189745
DOI: 10.1128/mbio.02060-24

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