Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absence of hepatitis B virus precore mutants in patients with chronic hepatitis B responding to interferon-alpha.

Hepatology (Baltimore, Md.) - 1 Jun 1992

Xu J, Brown D, Harrison T, Lin Y, Dusheiko G

Abstract excerpt

Precore defective HBV mutants may gradually prevail because of immune selection and explain spontaneous seroconversion from HBeAg to anti-HBe in HBV carriers. We have analyzed whether the presence of precore HBV mutants is a determinant of responsiveness to interferon-alpha therapy. Fifteen carriers (nine responders and six nonresponders) who were treated with interferon-alpha were examined. Serum samples were...

Topics

Adult
Chronic Disease
Female
Genes, Viral
Hepatitis B
Hepatitis B Core Antigens
Hepatitis B e Antigens
Hepatitis B virus
Humans
Interferon-alpha
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Remission Induction

Source

Identifiers

PMID: 1592338
DOI: 10.1002/hep.1840150605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1592338-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of hepatitis B virus precore mutants in patients with chronic hepatitis B responding to interferon-alpha.PMID 1592338Read ↗

Hepatitis B virus precore mutants in HBeAg carriers with chronic hepatitis treated with interferon.Semantic proximity Read ↗

Hepatitis B virus unable to secrete e antigen and response to interferon in chronic hepatitis B.Semantic proximity Read ↗

Hepatitis B virus precore/core variation and interferon therapy.Semantic proximity Read ↗

Prevalence of precore mutants in anti-HBe-positive hepatitis B virus carriers in Germany.Semantic proximity Read ↗

Distribution of the predominant hepatitis B virus precore variants in hepatitis B e antigen-positive children and their effect on treatment response.Semantic proximity Read ↗

Genomic variations in precore and cytotoxic T lymphocyte regions in chronic hepatitis B in relationship to interferon responsiveness.Semantic proximity Read ↗

Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy.Semantic proximity Read ↗

Low frequency of precore hepatitis B virus mutants in anti-hepatitis B e-positive reactivation after loss of hepatitis B e antigen in patients with chronic hepatitis B.Semantic proximity Read ↗

Hepatitis B virus precore mutations and HBeAg negative reactivation of chronic hepatitis B after interferon therapy.Semantic proximity Read ↗

The precore mutation is associated with severity of liver damage in Brazilian patients with chronic hepatitis B.Semantic proximity Read ↗

Genetic heterogeneity in the precore region of hepatitis B virus in hepatitis B e antigen-negative chronic hepatitis B patients: spontaneous seroconversion and interferon-induced seroconversion.Semantic proximity Read ↗

Analysis of hepatitis B virus precore variants in hepatitis B e antibody-positive patients treated with prednisone plus interferon.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.