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Article

Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection

27 Jun 2018

Abstract excerpt

Chronic delta hepatitis, caused by hepatitis delta virus (HDV), is the most severe form of viral hepatitis, affecting at least 20 million hepatitis B virus (HBV)-infected patients worldwide. HDV/HBV co- or superinfections are major drivers for hepatocarcinogenesis. Antiviral treatments exist only for HBV and can only suppress but not cure infection. Development of more effective therapies has been impeded by the...

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PMID: 29950446
DOI: 10.1126/scitranslmed.aap9328

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