Article
Molecular identification of latent precancers in histologically normal endometrium.
Cancer research - 1 Jun 2001
Mutter G L, Ince T A, Baak J P, Kust G A, Zhou X P, Eng C
Abstract excerpt
Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between...
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