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Article

Emergence, involution, and progression to carcinoma of mutant clones in normal endometrial tissues.

Cancer research - 15 May 2014

Mutter George L, Monte Nicolas M, Neuberg Donna, Ferenczy Alex, Eng Charis

Abstract excerpt

Sporadic somatic inactivation of genes such as PTEN within histologically normal endometrium (latent precancers) is an early step in endometrial carcinogenesis. We have used clone-specific mutations of PTEN to determine the fate of latent precancers over time in women who do (high risk) and do not (low risk) develop endometrial neoplasia. PTEN immunohistochemistry was performed on 45 occurrences of endometrial...

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Source

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Identifiers

PMID: 24662919
DOI: 10.1158/0008-5472.CAN-14-0108
PMCID: PMC4058864

Genes

PTEN

Provenance

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