Article
Colorectal cancer: using blood samples and tumor tissue to detect K-ras mutations.
Expert review of anticancer therapy - 1 Jun 2015
Li Yang, Fu Xiao-Hong, Yuan Jin-Qiu, Yang Zu-Yao, Mao Chen, Dong Xiao-Mei, Tang Jin-Ling, Wang Sheng-Yong
Abstract excerpt
We performed a meta-analysis to assess whether blood can be substituted for tumor tissue in K-ras mutation testing. PubMed, EMBASE, MEDLINE, and BIOSIS databases were searched. Twenty-three studies including 1261 patients were included. The pooled overall sensitivity, specificity, and concordance rate were 0.69 (95% CI: 0.59-0.78), 0.96 (95% CI: 0.93-0.97), and 0.86 (95% CI: 0.82-0.89), respectively. Subgroup...
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