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Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21 <sup>WAF1/CIP1</sup>

6 Jun 2000

Abstract excerpt

Angiogenesis has been demonstrated to be essential for tumor growth and metastasis, and inhibition of angiogenesis is emerging as a promising strategy for treating cancer. Among the most potent inhibitors of angiogenesis is the fumagillin family of natural products. An analog of fumagillin, known as TNP-470 or AGM-1470, has been undergoing clinical trials for treating a variety of cancers. TNP-470 has been shown...

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PMID: 10841547
DOI: 10.1073/pnas.97.12.6427

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