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Molecular mechanisms of G<sub>0</sub>/G<sub>1</sub> cell‐cycle arrest and apoptosis induced by terfenadine in human cancer cells

23 Apr 2003

Abstract excerpt

Terfenadine (TF), a highly potent histamine H1 receptor antagonist, has been shown to exert no significant central nervous system side effects in clinically effective doses. In this study, we demonstrated that TF induced significant growth inhibition of human cancer cells, including Hep G2, HT 29, and COLO 205 cells, through induction of G(0)/G(1) phase cell-cycle arrest. The minimal dose of TF induced...

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PMID: 12720299
DOI: 10.1002/mc.10118

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