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The Development of MetAP-2 Inhibitors in Cancer Treatment

1 Mar 2012

Abstract excerpt

Methionine aminopeptidases (MetAPs), which remove methionine residue from newly synthesized polypeptide chains, are a class of metalloproteases ubiquitously distributed in both eukaryotes and prokaryotes. MetAP-2 inhibition can induce G1 cell cycle arrest, cytostasis in tumor cells in vitro and inhibition of tumor growth in vivo. The discovery of fumagillin with potent antiangiogenic and antiproliferative...

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PMID: 22229417
DOI: 10.2174/092986712799320709

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