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Article

Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37.

Chemistry & biology - 28 Oct 2011

Sundberg Thomas B, Darricarrere Nicole, Cirone Pasquale, Li Xia, McDonald Lucy, Mei Xue, Westlake Christopher J, Slusarski Diane C, Beynon Robert J, Crews Craig M

Abstract excerpt

Identification of methionine aminopeptidase-2 (MetAP-2) as the molecular target of the antiangiogenic compound TNP-470 has sparked interest in N-terminal Met excision's (NME) role in endothelial cell biology. In this regard, we recently demonstrated that MetAP-2 inhibition suppresses Wnt planar cell polarity (PCP) signaling and that endothelial cells depend on this pathway for normal function. Despite this...

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Identifiers

PMID: 22035799
DOI: 10.1016/j.chembiol.2011.07.020
PMCID: PMC3205358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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