Article
Diversity in neuroanatomical distribution of abnormal prion protein in atypical scrapie.
PLoS pathogens - 1 Jun 2007
Nentwig Alice, Oevermann Anna, Heim Dagmar, Botteron Catherine, Zellweger Karola, Drögemüller Cord, Zurbriggen Andreas, Seuberlich Torsten
Abstract excerpt
Scrapie is a transmissible spongiform encephalopathy (TSE) in sheep and goats. In recent years, atypical scrapie cases were identified that differed from classical scrapie in the molecular characteristics of the disease-associated pathological prion protein (PrP(sc)). In this study, we analyze the molecular and neuropathological phenotype of nine Swiss TSE cases in sheep and goats. One sheep was identified as...
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