Article
Radial glial identity is promoted by Notch1 signaling in the murine forebrain.
Neuron - 1 May 2000
Gaiano N, Nye J S, Fishell G
Abstract excerpt
In vertebrates, Notch signaling is generally thought to inhibit neural differentiation. However, whether Notch can also promote specific early cell fates in this context is unknown. We introduced activated Notch1 (NIC) into the mouse forebrain, before the onset of neurogenesis, using a retroviral vector and ultrasound imaging. During embryogenesis, NIC-infected cells became radial glia, the first specialized cell...
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