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Article

The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential

4 Mar 2014

Abstract excerpt

N-myc (MYCN), a member of the Myc family of basic-helix-loop-helix-zipper (bHLHZ) transcription factors, is a central regulator of many vital cellular processes. As such, N-myc is well recognized for its classic oncogenic activity and association with human neuroblastoma. Amplification and overexpression of N-myc has been described in other tumor types, particularly those of neural origin and neuroendocrine...

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PMID: 24589438
DOI: 10.1158/1541-7786.mcr-13-0536

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Targeting MYCN in Molecularly Defined Malignant Brain TumorsSemantic proximity Read ↗

Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastomaSemantic proximity Read ↗

p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic SignificanceSemantic proximity Read ↗

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