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Article

Polyunsaturated fatty acids inhibit PI3K activity in a yeast-based model system.

Biotechnology journal - 1 Aug 2009

Couplan Elodie, Le Cann Marie, Le Foll Christelle, Corporeau Charlotte, Blondel Marc, Delarue Jacques

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) pathway controls the regulation of cell growth, proliferation, migration and apoptosis. In many tumors, the PI3K gene is mutated or overexpressed, and/or the PI3K pathway is hyperactive. PI3K is therefore a potential pharmacological target for the development of anti-tumor drugs. Some polyunsaturated fatty acids (PUFA), when given in the diet, may lead to a decrease in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19557793
DOI: 10.1002/biot.200800229

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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