Article
Analysis of a positional candidate gene for inflammatory bowel disease: NRAMP2.
Inflammatory bowel diseases - 1 May 2000
Stokkers P C, Huibregtse K, Leegwater A C, Reitsma P H, Tytgat G N, van Deventer S J
Abstract excerpt
Genome scans have identified a region spanning 40 cM on the long arm of chromosome 12 as a susceptibility locus for inflammatory bowel disease (IBD). This locus contains several candidate genes for IBD, one of which is the gene for the natural resistance associated macrophage protein 2 (NRAMP2). This protein is a divalent cation transporter and is expressed in many cells and tissues. The putative role of this...
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